2024
Yiğit Kutlu, Gabriel Axel, Rachel Kolodny3, Nir Ben-Tal, Turkan Haliloglu
Reused Protein Segments Linked to Functional Dynamics
Molecular Biology and Evolution, Volume 41, Issue 9, msae184, https://doi.org/10.1093/molbev/msae184, 2024.
Roth, O., Yechezkel, S., Serero, O., Eliyahu, A., Vints, I., Tzeela, P., Carignano, A., Janacek, D. P., Peters, V., Kessel, A., Dwivedi, V., Carmeli-Weissberg, M., Shaya, F., Faigenboim-Doron, A., Ung, K. L., Pedersen, B. P., Riov, J., Klavins, E., Dawid, C., Hammes, U. Z., & 4 others
Nat Biotechnol . https://doi.org/10.1038/s41587-023-02065-3, 2024.
Peleg Ragonis-Bachar, Gabriel Axel, Shahar Blau, Nir Ben-Tal, Rachel Kolodny, Meytal Landau
What can AlphaFold do for antimicrobial amyloids?
Proteins.2024;92:265–281, 2024.
Ben-Tal, N.
AI-based view of protein space. An item within Voices on “What can recent methodological advances help us understand about protein and genome evolution?”
Cell Systems, 15 (3): 205-210, 2024, https://doi.org/10.1016/j.cels.2024.02.006. https://www.sciencedirect.com/science/article/pii/S2405471224000607
2023
Barak Yariv, Elon Yariv, Amit Kessel, Gal Masrati, Adi Ben Chorin, Eric Martz, Itay Mayrose, Tal Pupko, Nir Ben-Tal
Using evolutionary data to make sense of macromolecules with a “face-lifted” ConSurf
Protein Science. 2023;32:e4582. https://doi.org/10.1002/pro.4582, 2023
Identification and Analysis of Fungal-Specific Regions in the Aspergillus fumigatus Cu Exporter CrpA That Are Essential for Cu Resistance but Not for Virulence
Int. J. Mol. Sci. 2023, 24, 3705. https://doi.org/10.3390/ijms24043705, 2023
Gal Masrati, Amit Kessel and Nir Ben-Tal
Cation/proton antiporters: novel structure-driven pharmaceutical opportunities
Trends in Pharmacological Sciences https://doi.org/10.1016/j.tips.2023.02.006, 2023
Natan Nagar, Jérôme Tubiana, Gil Loewenthal, Haim J. Wolfson, Nir Ben Tal, Tal Pupko
EvoRator2: predicting site-specific amino acid substitutions based on protein structural information using deep learning
YJMBI 168155, https://doi.org/10.1016/j.jmb.2023.168155 , 2023
Ayca Ersoy, Bengi Altintel , Nurit Livnat Levanon, Nir Ben-Tal, Turkan Haliloglu, Oded Lewinson
Computational analysis of long-range allosteric communications in CFTR
SSRN https://dx.doi.org/10.2139/ssrn.4487221 , 2023
Ersoy, Altintel, Livnat Levanon et al. eLife 12:RP88659. DOI: https://doi.org/10.7554/eLife.88659, 2023.
2020
Liam M. Longo, Jagoda Jabłońska, Pratik Vyas, Manil Kanade, Rachel Kolodny, Nir Ben-Tal, Dan S. Tawfik.
On the emergence of P-Loop NTPase and Rossmann enzymes from a Beta-Alpha-Beta ancestral fragment
eLife ;9:e64415. DOI: https://doi.org/10.7554/eLife.64415, 2020.
Gal Masrati, Ramakanta Mondal, Abraham Rimon, Amit Kessel, Etana Padan, Erik Lindahl and Nir Ben-Tal.
An angular motion of a conserved four-helix bundle facilitates alternating access transport in the TtNapA and EcNhaA transporters
PNAS, https://www.pnas.org/content/early/2020/11/24/2002710117, 2020.
Yaniv Lustig, Shlomit Keler, Rachel Kolodny, Nir Ben-Tal, Danit Atias-Varon, Ekaterina Shlush, Motti Gerlic, Ariel Munitz , Ram Doolman, Keren Asraf , Liran I. Shlush and Asaf Vivante
Potential antigenic cross-reactivity between SARS-CoV-2 and Dengue viruses
Clinical Infectious Diseases, ciaa1207, https://doi.org/10.1093/cid/ciaa1207, 2020.
Burcin Acar, Jessica Rose,Burcu Aykac Fas, Nir Ben-Tal,Oded Lewinson, Turkan Haliloglu
Distinct Allosteric Networks Underlie Mechanistic Speciation of ABC Transporters
Structure https://doi.org/10.1016/j.str.2020.03.014, 2020.
Siwar Sabrialabed, Janet G. Yang, Elon Yariv, Nir Ben-Tal, and Oded Lewinson
Substrate recognition and ATPase activity of the E. coli cysteine/cystine ABC transporter YecSC-FliY
J. Biol. Chem. https://www.jbc.org/cgi/doi/10.1074/jbc.RA119.012063, 2020.
Aya Narunsky, Amit Kessel, Ron Solan, Vikram Alva, Rachel Kolodny and Nir Ben-Tal
On the evolution of protein–adenine binding
PNAS https://doi.org/10.1073/pnas.1911349117, 2020.
T. C. Marcink, E. Yariv, K. Rybkina, V. Más, F. T. Bovier, A. des Georges, A. L. Greninger, C. A. Alabi, M. Porotto, N. Ben-Tal, A. Moscona
Hijacking the Fusion Complex of Human Parainfluenza Virus as an Antiviral Strategy
mBio . DOI: 10.1128/mBio.03203-19, 2020.
Maria Littmann, Katharina Selig, Liel Cohen-Lavi, Yotam Frank, Peter Hönigschmid, Evans Kataka, Anja Mösch, Kun Qian, Avihai Ron, Sebastian Schmid, Adam Sorbie, Liran Szlak, Ayana Dagan-Wiener, Nir Ben-Tal, Masha Y. Niv, Daniel Razansky, Björn W. Schuller, Donna Ankerst, Tomer Hertz & Burkhard Rost
Validity of machine learning in biology and medicine increased through collaborations across fields of expertise
Nature Machine Intelligence,https://doi.org/10.1038/s42256-019-0139-8, 2020
Adi Ben Chorin, Gal Masrati, Amit Kessel, Aya Narunsky, Josef Sprinzak, Shlomtzion Lahav, Haim Ashkenazy, Nir Ben-Tal
ConSurf-DB: An accessible repository for the evolutionary conservation patterns of the majority of PDB proteins
Protein Science, 29:258–267,https://doi.org/10.1002/pro.3779, 2020.
2021
Anastasiya Kuznetsova, Gal Masrati, Elena Vigonsky, Nurit Livnat-Levanon, Jessica Rose, Moti Grupper, Adan Baloum, Janet G. Yang, Douglas C. Rees, Nir Ben-Tal, Oded Lewinson
Titratable transmembrane residues and a hydrophobic plug are essential for manganese import via the Bacillus anthracis ABC transporter MntBC-A
J. Biol. Chem. https://doi.org/10.1016/j.jbc.2021.101087 297(4) 10108, 2021.
Nir Ben-Tal, Daisuke Kihara and Arun Prasad Pandurangan
Editorial: Computational Approaches to Study the Impact of Mutations on Disease and Drug Resistance
Front. Mol. Biosci. 8:813552.https://doi.org/10.3389/fmolb.2021.813552, 2021.
Rose C. Hadley, Daniel Zhitnitsky, Nurit Livnat-Levanon, Gal Masrati, ElenaVigonsky, Jessica Rose, Nir Ben-Ta, lAmy C. Rosenzweig
and Oded Lewinson
The copper-linked E. coli AZY operon: Structure, metal binding, and a possible physiological role in copper delivery
JBC, https://doi.org/10.1016/j.jbc.2021.1014459, 2021.
Neeraj Sharma, Chaitanya Patel, Marina Shenkman, Amit Kessel, Nir Ben-Tal and Gerardo Z. Lederkremer
The Sigma-1 receptor is an ER-localized type II membrane protein
JBC, https://doi.org/10.1016/j.jbc.2021.101299, 2021.
Maya Rubin and Nir Ben-Tal
Using ConSurf to Detect Functionally Important Regions in RNA
Current Protocols, 1, e270.https://doi.org/10.1002/cpz1.270, 2021.
Ron Solan, Joana Pereira, Andrei N. Lupas, Rachel Kolodny and Nir Ben-Tal
Gram-negative outer-membrane proteins with multiple β-barrel domains
PNAS Vol. 118 No. 31 e2104059118, https://doi.org/10.1073/pnas.2104059118, 2021.
R. Mondal, A. Rimon, G. Masrati, N. Ben-Tal, A. Friedler and E. Padan
Towards Molecular Understanding of thepH Dependence Characterizing NhaA of Which Structural Fold is Shared by Other Transporters
Journal of Molecular Biology 433 (2021) 1671563, https://doi.org/10.1016/j.jmb.2021.167156, 2021.
Gal Masarati, Meytal Landau, Nir Ben-Tal, Andrei Lupas, Mickey Kosloff and Jan Kosinsky
Integrative structural biology in the era of accurate structure prediction
Journal of Molecular Biology https://doi.org/10.1016/j.jmb.2021.167127, 2021.
Nir Ben-Tal and Andrei N Lupas
Editorial overview: Sequences and topology: ‘paths from sequence to structure
Current Opinion in Structural Biology 68:vi–viii, https://doi.org/10.1016/j.sbi.2021.05.005, 2021.
Michael Bernhofer, Christian Dallago, Tim Karl, Venkata Satagopam, Michael Heinzinger, Maria Littmann, Tobias Olenyi, Jiajun Qiu, Konstantin Schütze, Guy Yachdav, Haim Ashkenazy, Nir Ben-Tal, Yana Bromberg, Tatyana Goldberg, Laszlo Kajan, Sean O’Donoghue, Chris Sander, Andrea Schafferhans, Avner Schlessinger, Gerrit Vriend, Milot Mirdita, Piotr Gawron, Wei Gu, Yohan Jarosz, Christophe Trefois, Martin Steinegger, Reinhard Schneider, Burkhard Rost
PredictProtein - Predicting Protein Structure and Function for 29 Years
Nucleic Acids Research, gkab354, https://doi.org/10.1093/nar/gkab354, 2021.
Yiǧit Kutlu, Nir Ben-Tal, and Turkan Haliloglu
Global Dynamics Renders Protein Sites with High Functional Response
J. Phys. Chem, https://doi.org/10.1021/acs.jpcb.1c02511, 2021.
Rachel Kolodny, Sergey Nepomnyachiy, Dan S. Tawfik, Nir Ben-Tal.
Bridging Themes: Short Protein Segments Found in Different Architectures
Molecular Biology and Evolution, Volume 38, Issue 6, June 2021, Pages 2191–2208, https://doi.org/10.1093/molbev/msab017
Hadarovich A, Chakravarty D, Tuzikov AV, Ben-Tal N, Kundrotas PJ, Vakser IA
Structural motifs in protein cores and at protein–protein interfaces are different
Protein Science, https://doi.org/10.1002/pro.3996 2021.
Klara Papouskova, Michaela Moravcova, Gal Masrati, Nir Ben-Tal, Hana Sychrova, Olga Zimmermannova.
C5 conserved region of hydrophilic C-terminal part of Saccharomyces cerevisiae Nha1 antiporter determines its requirement of Erv14 COPII cargo receptor for plasma-membrane targeting
Molecular Microbiology,https://doi.org/10.1111/mmi.14595, 2021.
Ido Caspy, Tom Schwartz, Vinzenz Bayro-Kaiser, Mariia Fadeeva, Amit Kessel, Nir Ben-Tal & Nathan Nelson
Dimeric and high-resolution structures of Chlamydomonas Photosystem I from a temperature-sensitive Photosystem II mutant
Commun Biol 4, 1380 https://doi.org/10.1038/s42003-021-02911-7, 2021.
2022
Diego Velázquez, Vojtěch Průša, Gal Masrati, Elon Yariv, Hana Sychrova, Nir Ben-Tal, Olga Zimmermannova
Allosteric links between the hydrophilic N-terminus and transmembrane core of human Na+/H+ antiporter NHA2
Protein Science. 2022;31:e4460, https://doi.org/10.1002/pro.4460, 2022
Kaiyu Qiu, Nir Ben-Tal and Rachel Kolodny
Similar protein segments shared between domains ofdifferent evolutionary lineages
Protein Science. 31(9):e4407.https://doi.org/10.1002/pro.440710 of 10QIUET AL., 2022
Nir Ben-Tal and Rachel Kolodny
Homologues not needed: Structure prediction from a protein language model
Structure, Volume 30, Issue 8, Pages 1047-1049, https://doi.org/10.1016/j.str.2022.07.002, 2022
Natan Nagar, Nir Ben-Tal and Tal Pupko
EvoRator: Prediction of Residue-level Evolutionary Rates from Protein Structures Using Machine Learning
Journal of Molecular Biology, https://doi.org/10.1016/j.jmb.2022.167538, 2022.
Omri Shelef, Sara Gutkin, Daniel Feder, Ariel Ben-Bassat, Michal Mandelboim, Yoni Haitin, Nir Ben-Tal, Eran Bacharach, Doron Shabat.
Ultrasensitive chemiluminescent neuraminidase probe for rapid screening and identification of small-molecules with antiviral activity against influenza A virus in mammalian cells
Chem. Sci., 2022, 13, 12348 ,DOI: 10.1039/d2sc03460c, 2022.
Using evolutionary data to make sense of macromolecules with a ‘face-lifted’ ConSurf
Protein Science DOI10.1002/pro.4582